{"id":127,"date":"2021-02-16T04:36:34","date_gmt":"2021-02-16T04:36:34","guid":{"rendered":"http:\/\/scdtoolkit.jh.edu\/?page_id=127"},"modified":"2022-10-29T17:22:12","modified_gmt":"2022-10-29T17:22:12","slug":"sickle-cell-disease-modifying-treatments","status":"publish","type":"page","link":"https:\/\/scdtoolkit.jh.edu\/?page_id=127","title":{"rendered":"Sickle Cell Disease Modifying Treatments"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<figure class=\"wp-block-pullquote is-style-default\"><blockquote><p>The goal for you is to understand the study designs, what to monitor, and how to overall manage FDA-approved novel therapies used in the management of sickle cell disease.<\/p><\/blockquote><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<p style=\"font-size:26px\">1. Listen and Review slides for <em>Disease Modifying Therapies<\/em> <em>in Sickle Cell Disease<\/em> by Sophie Lanzkron, MD, MHS.<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-video\"><video height=\"1080\" style=\"aspect-ratio: 1920 \/ 1080;\" width=\"1920\" controls src=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/02\/zoom_0.mp4\"><\/video><\/figure>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Management-of-SCD.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of Management of SCD..\"><\/object><a id=\"wp-block-file--media-a9a00d20-fda5-42b6-9c97-b20ca64c090a\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Management-of-SCD.pdf\">Management of SCD<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Management-of-SCD.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-a9a00d20-fda5-42b6-9c97-b20ca64c090a\">Download<\/a><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">2. Review below supplemental materials:<\/h2>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/hydroxyurea-2.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of Expert Panel Report 2014: Guidelines on Hydroxyurea..\"><\/object><a id=\"wp-block-file--media-811a81c4-c568-44b9-9e2c-8ff82a81e863\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/hydroxyurea-2.pdf\">Expert Panel Report 2014: Guidelines on Hydroxyurea<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/hydroxyurea-2.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-811a81c4-c568-44b9-9e2c-8ff82a81e863\">Download<\/a><\/div>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/Voxelotor.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of New England Journal of Medicine: Voxelotor ..\"><\/object><a id=\"wp-block-file--media-ecb50a9b-1aaf-40e8-9f6a-34ffbbac2769\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/Voxelotor.pdf\">New England Journal of Medicine: Voxelotor <\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/Voxelotor.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-ecb50a9b-1aaf-40e8-9f6a-34ffbbac2769\">Download<\/a><\/div>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/A-Phase-3-Trial-of-l-Glutamine-in-Sickle-Cell-Disease.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of New England Journal of Medicine: L-Glutamine..\"><\/object><a id=\"wp-block-file--media-8d66cf7d-dc90-40ae-b778-2daa58ddc7d3\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/A-Phase-3-Trial-of-l-Glutamine-in-Sickle-Cell-Disease.pdf\">New England Journal of Medicine: L-Glutamine<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/A-Phase-3-Trial-of-l-Glutamine-in-Sickle-Cell-Disease.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-8d66cf7d-dc90-40ae-b778-2daa58ddc7d3\">Download<\/a><\/div>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/Crizanlizumab-for-the-Prevention-of-Pain-Crises-in-Sickle-Cell-Disease.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of New England Journal of Medicine: Crizanlizumab..\"><\/object><a id=\"wp-block-file--media-b7ddb9b3-df3b-4a3f-a70e-2fab6bdbdab4\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/Crizanlizumab-for-the-Prevention-of-Pain-Crises-in-Sickle-Cell-Disease.pdf\">New England Journal of Medicine: Crizanlizumab<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2021\/12\/Crizanlizumab-for-the-Prevention-of-Pain-Crises-in-Sickle-Cell-Disease.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-b7ddb9b3-df3b-4a3f-a70e-2fab6bdbdab4\">Download<\/a><\/div>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/advancesadv2019001143.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of ASH 2020 Blood Transfusions and SCD..\"><\/object><a id=\"wp-block-file--media-34e52590-dd11-42ed-87c8-2195aa03f986\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/advancesadv2019001143.pdf\">ASH 2020 Blood Transfusions and SCD<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/advancesadv2019001143.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-34e52590-dd11-42ed-87c8-2195aa03f986\">Download<\/a><\/div>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Blood-Transfusion-and-SCD.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of NHLBI, 2014 Blood Transfusions and SCD..\"><\/object><a id=\"wp-block-file--media-0d0e8113-2269-421a-b40d-d141d78eeb3d\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Blood-Transfusion-and-SCD.pdf\">NHLBI, 2014 Blood Transfusions and SCD<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Blood-Transfusion-and-SCD.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-0d0e8113-2269-421a-b40d-d141d78eeb3d\">Download<\/a><\/div>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Therapeutic-Phlebotomy-Orderset.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of Therapeutic-Phlebotomy-Orderset..\"><\/object><a id=\"wp-block-file--media-a05fa068-ae5f-4c18-bf3b-b48bc6721000\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Therapeutic-Phlebotomy-Orderset.pdf\">Therapeutic-Phlebotomy-Orderset<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Therapeutic-Phlebotomy-Orderset.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-a05fa068-ae5f-4c18-bf3b-b48bc6721000\">Download<\/a><\/div>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Therapeutic-Phlebotomy-Protocol.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Embed of Therapeutic-Phlebotomy-Protocol..\"><\/object><a id=\"wp-block-file--media-a3ea43a3-d49d-454c-9eb4-1051152e486f\" href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Therapeutic-Phlebotomy-Protocol.pdf\">Therapeutic-Phlebotomy-Protocol<\/a><a href=\"https:\/\/scdtoolkit.jh.edu\/wp-content\/uploads\/2022\/10\/Therapeutic-Phlebotomy-Protocol.pdf\" class=\"wp-block-file__button\" download aria-describedby=\"wp-block-file--media-a3ea43a3-d49d-454c-9eb4-1051152e486f\">Download<\/a><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/scdtoolkit.jh.edu\/\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#450102\" class=\"has-inline-color\">ALL DONE? Click HEre to return to the Main screen<\/mark><\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The goal for you is to understand the study designs, what to monitor, and how to overall manage FDA-approved novel therapies used in the management of sickle cell disease. 1. Listen and Review slides for Disease Modifying Therapies in Sickle Cell Disease by Sophie Lanzkron, MD, MHS. 2. Review below supplemental materials:<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-127","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=\/wp\/v2\/pages\/127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=127"}],"version-history":[{"count":10,"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=\/wp\/v2\/pages\/127\/revisions"}],"predecessor-version":[{"id":885,"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=\/wp\/v2\/pages\/127\/revisions\/885"}],"wp:attachment":[{"href":"https:\/\/scdtoolkit.jh.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}